Formulation, Optimization & Evaluation of Transdermal Patches of Salbutamol Sulphate

Aim: The objective of the present research work was to formulate and compare two different kinds of penetration enhancer in transdermal patch with placebo patch using a drug (Salbutamol sulphate) and compare for in vitro drug release. Study Design: The transdermal patches of Salbutamol sulphate were prepared by solvent evaporation technique using different ratios of Hydroxy propyl methylcellulose (HPMC K15M) and Poly vinyl propylene (PVP K30). The prepared transdermal patches were evaluated on parameters like weight variation, thickness uniformity, moisture content, moisture uptake, folding endurance, tensile strength, drug content, in vitro dissolution studies, in vitro drug release, skin irritation test and stability studies. Maximum drug release was showed by Batch T, and the optimized formulation showed satisfactory characteristics. INTRODUCTION: Transdermal drug delivery systems (TDDS) is type of drug delivery system designed to deliver a therapeutically effective amount of drug across a patient’s skin. Typically, the Transdermal patches, stored in a pouch; at the time of use, the pouch is opened and patches applied to skin to releases the drug. The Transdermal patches, typically consists of a release liner (e.g. polyester), adhesive (e.g. polyisobutylene-based, acrylic, silicone-based), active pharmaceutical ingredient (i.e. drug), and backing (e.g. polyester). The system may also contain penetration enhancers, excipients, a ratecontrolling membrane, and a protective film over the backing and over the release liner. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.7(4).1572-79 Article can be accessed online on: www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.7 (4).1572-79 Adhesive properties of patches can be affected by the type and concentration of additives used, thickness of the adhesive, type and concentration of permeation enhancers. Composition, thickness of the backing layer, residual solvent, type and concentration of the active pharmaceutical ingredient, give an impact on patch properties 1 . Transdermal route get advantage over conventional drug delivery system because it lowers the risk of toxicity or inefficacy in the case of drugs with narrow therapeutic window by providing the constant blood levels in plasma and also improves patient compliance by improving dosage regimens. In case of the drugs which have low bioavailability due to first-pass metabolism in the gastrointestinal tract and liver or short biological half-lives to be administered at most, once a day. The problems of the gastrointestinal environment, such as chemical degradation of the drug and gastric irritation, are avoided and drug input can be easily terminated by removing the patch from stratum corneum. Transdermal route is noninvasive alternative to